In situ generation of Mes2Mg as a non-nucleophilic carbon-centred base reagent for the efficient one-pot conversion of ketones to silyl enol ethers.
نویسندگان
چکیده
Treatment of commercially available MesMgBr with 1,4-dioxane produces the key Mes(2)Mg reagent in situ which then mediates the deprotonation of ketones to deliver trimethylsilyl enol ethers, at readily accessible temperatures and without any nucleophilic addition, in an expedient and high yielding one-pot process.
منابع مشابه
Bismesitylmagnesium: a thermally stable and non-nucleophilic carbon-centred base reagent for the efficient preparation of silyl enol ethers.
Bismesitylmagnesium has been established as an accessible, practical, convenient, and non-nucleophilic carbon-centred base reagent for efficient access to silyl enol ethers from a series of ketone substrates at readily utilisable temperatures.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 6 7 شماره
صفحات -
تاریخ انتشار 2008